Tampa is a major city in, and the county seat of, Hillsborough County, Florida, United States. It is on the west coast of Florida on Tampa Bay, near the Gulf of Mexico, and is the largest city in the Tampa Bay Area. The city had a population of 335,709 at the 2010 census, and an estimated population of 377,165 in 2016.Archaeological evidence indicates the shores of Tampa Bay were inhabited by indigenous peoples for thousands of years. The Safety Harbor culture developed in the area around the year 1000 AD, and the descendant Tocobaga and Pohoy chiefdoms were living in or near the current city limits of Tampa when the area was first visited by Spanish explorers in the 16th century. Interactions between native peoples and the Spanish were brief and often violent, and although the newcomers did not stay for long, they introduced European diseases which brought the collapse of native societies across the Florida peninsula over the ensuing decades. Although Spain claimed all of Florida and beyond as part of New Spain, it did not found a colony on the west coast. After the disappearance of the indigenous populations, there were no permanent settlements in the Tampa Bay area until after the United States acquired Florida from Spain in 1821.